CLEVELAND, Ohio- The U.S. Food and Drug Administration has granted approval of a drug that experts say marks a landmark shift in treatment for the most common form of liver disease.

Madrigal Pharmaceuticals, a small pharmaceutical company in Pennsylvania was granted approval for its one and only drug: Rezdiffra (resmetirom), the first and only approved drug for the treatment for a serious form of fatty liver disease in adults.

University Hospitals liver specialist Dr. Pierre Gholam said the drug is designed to help prevent progression to cirrhosis in persons with fatty liver who have already shown some liver dysfunction -- somewhere between 8 and 10 million patients. These patients often have difficulty losing weight, which up until Thursday was the only intervention proven to be effective.

This is a big deal because fatty liver is by far the leading condition we see in the treatment of liver disease, said Gholam, of the approval announced last week.

Out of 56 patients he saw in his liver clinic last week, 34 of them had fatty liver, he recounted. Where else do you see a situation where two-thirds of your patients have the exact same problem?

Fatty liver is seen most often in people who are overweight or obese and is becoming more common around the world, especially in Middle Eastern and Western nations as the number of people with obesity rises.

Initially there may be no symptoms, but some people with fatty liver can develop a more severe form of the disease called nonalcoholic steatohepatitis, or NASH. When this happens, the fat in the liver becomes toxic, and liver cells become inflamed and die. NASH can lead to cirrhosis, liver failure, the need for a transplant, and even death.

The new drug works by stimulating the thyroid to burn excess energy that the liver would otherwise store in the form of fat. In patients with NASH, it has been shown to prevent and even reverse liver damage.

However, it is not currently approved in patients whose liver damage has progressed to cirrhosis, and the dosage of certain other medications, like statins used for lowering cholesterol, may need to be adjusted. Madrigal says, they are currently investigating whether the drug can help patients with cirrhosis.

It doesnt work for every patient. It works for a subset of patients, explained Gholam. But when it does it reduces inflammation and scarring in the liver which is ultimately what leads to patients developing cirrhosis and getting sick from fatty liver disease.

The drug manufacturers say that it should not be considered a substitute for modifications in diet and exercise, but instead used as a complementary treatment to help nudge patients in the right direction. And for many patients this is a big relief.

On the morning following the FDAs announcement, Gholam says seven patients called his office asking if they could get on the drug, which demonstrates just how many people are desperate for a solution.

Its the first step after 15-20 years of trying and failing said Gholam. Its a small first step. We have not cured fatty liver disease and we certainly have not cured metabolic syndrome or obesity, but it is the first time that someone is going to come to my clinic with fatty liver with scarring and Ill be able to offer them something other than diet and exercise.

Unfortunately, 90%-95% of people who lose weight regain it within three to five years he says.

So it is not a realistic expectation for most people, Gholam said.

Gholam says this marks the beginning of what may be a turning point in the treatment of fatty liver disease, and hes hopeful that a decade from now, patients will have multiple options.

GLP-1 agonists, like the drugs liraglutide and semaglutide currently prescribed to treat obesity and diabetes are also being investigated for their ability to treat the liver along with several other classes of medications Gholam said. The studies should have results in the next 10-18 months.

Meanwhile, data on Rezdiffra will continue to be collected for the FDA over the course of a total of 54 month because it was approved under the accelerated approval pathway, which allows for earlier approval of drugs that treat serious conditions and address an unmet medical need.

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When diet and exercise arent enough, new drug can treat fatty liver disease, says FDA - cleveland.com

Twilight star Ashley Greene knows it can be hard to get motivated for a workoutbut she does it anyway. Greene, 37, shared a video of herself wearing black leggings and a white t-shirt, doing a kettlebell workout at the gym. "Didn't feel 100 today but still got it in," reads the text over her Instagram story. Greene has detailed her fitness journey since welcoming daughter Kingsley in September 2022here's how the actress prioritizes her health and wellness.

Greene changes up her workouts to avoid boredom and fitness plateaus. "I started doing CorePower Yoga a lot because I feel like I'm getting all these little aches and pains if I'm not paying attention to stretching," she told Parade. "I like high-intensity interval training (HIIT) and for that I do STRONG by Zumba, which is right up my alley. I don't generally go into the classes, but I download them. There's a 60-minute one, there's a 20-minute one and there are some shorter ones too. And it's impossible for me to get a butt, but they have one geared towards that so I've started doing that one."

Greene loves clean beauty products. "Basically, I try to find things that are going to be clean and aren't going to include anything that doesn't need to be in there, and I love Beauty Counter for that reason," she told New York Magazine. "Each one of these oils serves a different purpose."

Greene is embracing her postpartum figure. "I am dedicated to putting in the work to rebuild a strong base," she wrote in an Instagram post. "I am also dedicated to giving myself grace and remaining eternally grateful for the beautiful life my body graciously helped me create and nurture. I don't think my body will ever be quite 'the same' and I'm learning to be ok with that." df44d9eab23ea271ddde7545ae2c09ec

Greene partnered with mental wellbeing platform Aura Health as mental health is a cause close to her heart. "I have always tried to be honest and vulnerable to help others not feel so alone, and this partnership with Aura Health is an example of that in its purest form," she said in a press release. "Opening up about my mental health journey was daunting but I am so proud to share my story on Aura and encourage others to care for their mental health with the help of the many features Aura Health has to offer."

HIIT is Greene's favorite workout. "What I love about HIIT is the fact that you can use your own body weight, which really works for me versus trying to lift a thousand pounds," she told Parade. "Whenever I work out with my body weight, I find that I can track how strong I'm becoming and I'm able to do things later in the week that I maybe wasn't able to in the beginning of the week. So for me, that's just a really fun thing to be able to track."

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Ashley Greene In Workout Gear Didn't Feel 100 Today But Still Got It In - Celebwell

Holly Madison refuses to talk about diet and exercise in front of her children credit:Bang Showbiz

Holly Madison refuses to talk about diets in front of her children.

The 44-year-old star - who was one of Hugh Hefner's girlfriends for 15 years at the famed home owned by the late magazine owner - has daughter Rainbow, 11, and seven-year-old son Forest with ex-husband Pasquale Rotella and explained that whilst she is "focused" on maintaining a healthy lifestyle, she won't discuss it in front of her kids.

She told Us Weekly: "Were really focused on healthy eating. Im really careful not to say anything about dieting or weight or anything in front of my kids. If theyre trying to shove something unhealthy in front of me, I just say, Oh, Im doing a health thing.

The former 'Girls Next Door' explained that she doesn't want her daughter to begin suffering from body image issues or seek "validation" through her appearance because she started to experience things like that when she was her age.

She said: "We dont want her to get into the mode where shes really focused on the way she looks, or trying to get attention for the way she looks or validation through that. I think weve been really successful so far. Shes on a better track than I was at that age for sure. I was already trying to look some sort of way when I was 11."

Holly was recently asked if it was true that the bathroom pipes had to be replaced from the amount of girls vomiting during their time in the mansion as they suffered from bulimia and she admitted it was "sad" to see so many women suffering at the time.

She said: "On my podcast, ['Girls Next Level with Bridget Marquardt'], we've talked to staff and other people who were there at the time that this allegedly happened, and I guess it was a thing. There were people who struggled with really bad eating disorders while I was there, and it was always a sad thing to see."

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Holly Madison reveals why she refuses to discuss diets in front of her kids - Yahoo News UK

People across the world are always curious about the British Royal Family and want to know as much about them as possible. That even includes wondering what they eat and how they exercise.

Princess Catherine (aka Kate Middleton) has previously revealed the secret to fitting exercise into her busy day. But how does a princess eat?

We were curious after she recently opened up about her health, revealing that she was undergoing treatment for cancer. With a bit of digging, we were able to put together an idea of what sort of foods are part of her diet!

Read more to see what kinds of foods Princess Catherine eats

Cosmopolitan did a bit of research into Princess Catherines diet and highlighted three different elements.

For starters, the royal reportedly eats a lot of home-cooked meals, and she is said to be a bit of a pro in the kitchen. Shes opened up about baking birthday cakes, and her roast chicken appears to be one of Prince Williams favorite dinners.

Princess Catherine has also been reported to enjoy a smoothie in the morning. One recipe that was referenced in the Daily Mail included spirulina, kale, matcha (a finely ground green tea powder), spinach, romaine, cilantro and blueberries.

The publication noted that the Prince and Princess of Wales are both sushi eaters.

What else do we know about Princess Catherines diet? The List noted that shes enjoys a spicy dish but is not a fan of almond milk. The more you know!

Last year Prince William revealed everything he ate in a day, which gave more insight into a royal diet!

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What Does Kate Middleton Eat? The Princess of Wales' Diet Revealed - Just Jared

Polycystic Ovary Syndrome (PCOS) affects millions of women worldwide, causing hormonal imbalances and a range of symptoms such as irregular periods, acne, and weight gain. While PCOS cannot be cured, its symptoms can be managed effectively through lifestyle changes, particularly focusing on diet and exercise. Adopting a PCOD diet and exercise plan is crucial for women with PCOS to alleviate symptoms and improve overall health.

We spoke to our expert Dr Kapil Dave, Director Sports - Sharda University to shed some light on the importance of diet and exercise in managing PCOD. Here is what he shared with us.

Choosing the right foods is essential for managing PCOS symptoms. A PCOD diet should primarily consist of unrefined, natural foods that are low in processed sugars and high in essential nutrients. Here are some dietary guidelines for women with PCOS:

Opt for whole grains, legumes, and minimally processed foods to stabilise blood sugar levels and improve insulin sensitivity.

Include fatty fish like tuna, salmon, sardines, and mackerel in your diet to reduce inflammation and support hormone regulation.

Load up on nutrient-dense greens such as spinach, kale, and broccoli to provide essential vitamins and minerals.

Also Read:World Down Syndrome Day 2024: 10 Tips for Caregiving Parents

Choose fruits like grapes, cherries, and berries that are rich in antioxidants and low in sugar to help manage insulin levels.

Incorporate sources of healthy fats such as coconut oil, olive oil, avocados, and nuts to support hormone production and maintain satiety.

Add anti-inflammatory spices like turmeric and cinnamon to your meals to reduce inflammation and improve insulin sensitivity.

Indulge in dark chocolate in moderation, as it contains antioxidants and may help regulate mood and cravings.

Minimise consumption of cakes, pastries, white bread, and other refined carbohydrate products to prevent spikes in blood sugar levels.

Also Read:Expert Shares 6 Health Benefits of Drinking Fennel Tea

Avoid fast food and fried foods such as fries, pizza, and burgers, which are high in unhealthy fats and contribute to weight gain.

Steer clear of processed meats like sausages and bacon, which can exacerbate inflammation and hormonal imbalances.

Limit intake of high-sugar fruits like bananas, mangoes, and jackfruit, as they can cause rapid increases in blood sugar levels.

Reduce consumption of red meat, pork, and ham, as they may contribute to insulin resistance and inflammation.

Exercise is an integral component of managing PCOS, as it helps improve insulin sensitivity, regulate hormones, and promote weight loss. Here are some exercise recommendations for women with PCOD:

Incorporate cardio workouts such as walking, running, swimming, cycling, or rowing into your routine to improve cardiovascular health and aid in weight management.

Include strength training exercises to build muscle mass, increase metabolism, and enhance insulin sensitivity.

Practice yoga asanas, meditation, and breathing exercises to reduce stress levels, improve mood, and promote relaxation.

Strengthen your core muscles through exercises like planks, crunches, and leg raises to support posture and stability.

Incorporate HIIT workouts into your routine to maximise calorie burn and improve cardiovascular fitness in less time.

It's essential for women with PCOS to consult with healthcare professionals, including dieticians and physicians, to develop a personalised diet and exercise plan tailored to their specific needs and goals. These experts can provide guidance on nutritional requirements, exercise intensity, and lifestyle modifications to effectively manage PCOS symptoms and improve overall health.

Adopting a PCOD diet and exercise plan is crucial for women with PCOS to alleviate symptoms, regulate hormones, and improve overall well-being. By making healthy food choices, engaging in regular physical activity, and seeking professional guidance, women with PCOD can take control of their health and enhance their quality of life.

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Managing PCOD: Expert Shares the Importance of Diet and Exercise - Onlymyhealth

An Australian nurse, who weighed about 115 kg, lost weight by making small dietary changes and doing simple exercises. She has lost almost 45 kg. Today, lets take a look at her diet and exercise plan. According to reports, the name of the woman is Samantha Abreu. She is 25 years old and hails from Melbourne. She had struggled with her weight problem since she was young. To improve her health, she started taking daily walks and changed her diet and included portion management. Samantha shared in a media interaction that she used to often binge eat and would fill up on cereal and toast after dinner. She added that she would get tired often and find it difficult to finish her 10-hour shifts at work.

Her life changed during the Covid-19 pandemic. Samantha, who was worried that she didnt want to turn like some elderly patients she would see in the hospital who wouldnt be able to walk after a fall, started going for daily walks for her mental health and realised it worked like magic for her mindset and body.

She slowly started incorporating portion control into her regular diet, decreasing the size of her meals, and dropping almost 45 kg in one year.

I see food as fuel now," she stated to SWNS.com.

She further said that by making a small change to her diet, she has made a great change to her health. As an example she said, she used to prepare a wrap pizza, as a healthy alternative to pizza when she felt hungry.

On TikTok, she talked about her whole diet and weight loss journey by following natural methods.

She said in a recent interaction with the New York Post that, Looking stronger is lovely. I hope other people can see themselves in me and realise they can slowly start implementing change; thats all I want."

Before: 115 kg

Breakfast: Bowl of cereal or toast

Lunch: Sandwich or dinner leftovers

Dinner: Roast snacks, cereal, toast, fast food

Now: 68 Kg

Breakfast: Oats and fruit

Lunch: Greek chicken pasta

Dinner: Chicken wrap pizza

She follows four weekly gym sessions, 10,000 steps a day, and five kilometre runs as part of her fitness routine.

first published: March 22, 2024, 18:24 IST

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Australian Woman Loses 45 Kg With This Simple Exercise And Diet Plan - News18

If you want to lose weight and gain muscle, having bathroom scales that provide precise measurements of your body fat percentage and muscle mass can be invaluable. One set of smart scales that does just that has been slashed by $70, now costing just $29.99 at Walmart.

In our 2023 review of the RENPHO Smart Scales we awarded them a high score of 4.5 out of 5 stars. We even called them "one of the best devices for measuring body fat that weve tested."

Regular scales will just give you one basic weight measurement, which can lead you to confuse muscle gain with fat gain. However, the RENPHO Smart Scales analyze 13 body composition metrics, including body fat, muscle mass, body water, visceral fat, and metabolic age.

You can then access health data provided by the scales through fitness apps like Apple Health, Google Fit, and Fitbit. Once you view body composition metrics on the app, its easier to set healthy goals and monitor your progress.

These particular RENPHO USB Rechargeable Smart Scales are also rechargeable, with multiple charging options so you dont need to worry about buying batteries.

Key features: 13 body composition metrics, 3 foot (1 meter) USB cable, user manual, LED display, data synced with popular fitness apps.

Consensus: Walmart customers gave the RENPHO USB Rechargeable Smart Scales 4.9 out of 5 stars. Many customers also commented on how "easy" the scales are to use.

Buy it if: You want to get an accurate picture of your body composition, such as your muscle mass and body fat. This could allow you to set health and fitness goals more easily and effectively.

Don't buy it if: The scales use popular health and fitness apps to sync health data. So if you dont have a smartphone or tablet that allows you to access such apps, these scales wont be for you.

Read more here:
One of our favorite smart scales for measuring body fat just got its price slashed in a Walmart deal - Livescience.com

Baxter Hosley and Thievin MacDonagh have died in a car crash. Police in Houston, Texas, say they were in a BMW driving over 100 miles an hour when it crashed and the car split in half. Both of their families stood side by side in a memorial video posted on the Ekkovision Instagram account, a supplement brand they worked for. The pair promoted health and fitness on multiple social media accounts. Inside Edition Digital has more.

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Fitness Influencers Baxter and Thievin Die in Car Crash - Yahoo! Voices

Gina Rodriguez's weight loss has been the talk of the town for years now. What you don't know is that she was diagnosed with hyperthyroidism at age 19 and Hashimoto's disease at age 26. Throughout her entire career, Gina Rodriguez has consistently remained physically robust and healthy.

This impacts the thyroid and can cause lethargy and weight gain, and she is now talking about how she handles it through a balanced diet and exercise routine.

Gina Rodriguez never set out to shed weight; rather, she has always attempted to live an active and healthy life, yet the world at large is abuzz with questions about the key to Gina Rodriguez's weight loss.

Gina Rodriguez's weight loss has sparked widespread interest due to her amazing transformation.

Before to the fourth season premiere of "Jane the Virgin," viewers were astounded by her remarkable weight loss. Gina credits her achievement to a controlled diet, tailored workout routines, and a focused mindset.

Her fitness programme combines aerobic and strength training, pushing people to achieve their own wellness and fitness goals. Gina worked closely with a dietitian to manage her cravings and maintain a balanced exercise programme.

Her path not only improved her physical appearance, but it also taught her the value of a positive mindset, setting reasonable objectives, and embracing self-love.

Acknowldging the struggles of keeping the weight off due to her health issues in a statement:

The Jane the Virgin actress opened up about what she does to manage her condition in the following statement:

She also revealed the diet that helps her lead a healthy lifestyle. Rodriguez modified her diet to better fit her health by limiting dairy and gluten.

Gina, who married Joe in 2019 and announced her pregnancy in July 2022, recently welcomed her firstborn, a son, at the beginning of the year 2023.

"This birthday hits differently," she posted the pregnancy announcement video during the time. She is now fully immersed in motherhood and celebrated her first Mother's Day on May 14, 2023.

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All about Jane the virgin star Gina Rodriguez's weight loss - Sportskeeda

Maintaining kidney health involves a balanced diet that supports overall well-being while managing specific dietary restrictions. A kidney-friendly diet typically emphasizes low-sodium, low-fat foods and includes plenty of fruits, vegetables, whole grains, and lean proteins. Limiting phosphorus, potassium, and protein intake may also be necessary, depending on individual needs.

Dr Roshan Kore, Consulting Dietician, NHSRCC Childrens Hospital, says, A balanced diet rich in whole grains, lean proteins, fruits, and vegetables is essential for maintaining kidney health. Limiting sodium, phosphorus, and potassium intake is crucial, as these can exacerbate kidney diseases. Incorporating foods like leafy greens, berries, fish, and low-fat dairy can provide essential nutrients while supporting kidney function."

One must adopt a balanced diet to prevent kidney diseases. Emphasizing low-sodium, low-fat, and low-cholesterol foods is crucial. Opting for fresh fruits and vegetables, whole grains, lean proteins like fish and poultry, and healthy fats such as those found in nuts and olive oil can promote kidney health. Incorporating foods rich in antioxidants like berries and leafy greens helps protect against oxidative stress," shares Dr Suparna Mukherjee, Charge, of Clinical Nutrition, Narayana Health City, Bangalore.

Hydration is also key; adequate water intake helps flush out toxins and prevents kidney stones. Avoiding processed foods, sugary drinks, and excessive alcohol consumption can further safeguard against kidney damage. Remember, a mindful approach to nutrition not only supports overall health but also plays a pivotal role in preventing and managing kidney diseases," adds Dr Kore.

Additionally, limiting processed foods, sugary beverages, and excessive protein intake can reduce the risk of kidney damage.

Remember, a wholesome diet is not only vital for overall health but also plays a pivotal role in safeguarding our kidneys for the long term," signs off Dr Mukherjee.

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Diet For Kidney Health: Foods To Consume And Avoid - News18