Fatty liver disease -- alongside fatty liver due to massive alcohol consumption -- is mainly caused by excessive consumption of fat and sugar combined with a lack of exercise or a sedentary life style. This is referred to as non-alcoholic fatty liver disease (NAFLD). If NAFLD becomes chronic -- e.g. through the constant uptake of high lipids and high sugar combined with lack of excercise a chronic inflammatory response is triggered in the liver tissue in addition. This can lead to non-alcoholic steatohepatitis (NASH) -- a liver disease with clear detectable pathologic alteratons of the tissue.

These liver diseases (NAFLD and NASH), along with chronic viral infections, are the most common causes of liver cancer, or hepatocellular carcinoma (HCC). In the United States, about 90 million people suffer from NAFLD. In Europe, the figure is more than 40 million, and even in threshold countries like India and China, the number of people affected is rising due to increasingly unhealthy lifestyles. More worrying, in all of the above mentioned states the numbers of NAFLD and NASH patients is constantly increasing. Consequently, the incidence of HCC resulting from NASH and NAFLD is also rising worldwide. In the United States, HCC is the fastest-growing form of cancer at the moment. No efficient causal therapy exists for HCC patients of which approximately 800,000 die every year.

T cells involved in the development of fatty liver disease, NASH and HCC

The mechanisms that cause diseases such as fatty liver disease, steatohepatitis and HCC are still not widely understood. However, immune cells, particularly CD8+ T cells and NK T cells seem to play an important role. This finding was made by a team of scientists led by Prof. Mathias Heikenwlder, Prof. Matthias Tschp, Dr. Kerstin Stemmer, Dr. Kristian Unger, Prof. Ulrike Protzer and the working group of Dr. Hans Zischka from the Helmholtz Zentrum Mnchen together with a team headed by Prof. Percy Knolle of the Technische Universitt Mnchen (TUM), Prof. Achim Weber from Zurich University Hospital and Dr. Monika Wolf, Institute of Surgical Pathology, University Hospital Zurich. The animal model which was used to examine the long-term effects of metabolic syndrome* enabled the scientists to elucidate new mechanisms that cause fatty liver disease and also show how it can develop into liver cancer.

Inflammatory events offer starting point for prevention and treatment

The scientists assume that an existing metabolic imbalance results in the activation and migration of immune cells to the liver. There, the immune cells interact with liver cells and trigger an inflammatory response that damages the liver tissue and also destabilizes the metabolic activity of the liver cells. "Initially it immune cells promote fatty liver degeneration. The inflammation, which is triggered by specific immune cells, encourages the progression of fatty liver pathology and causes NASH to develop. These processes are the basis for liver cell degeneration, which can cause HCC," explains Prof. Heikenwlder, who led the study. "Our results provide completely new insights into the development of these serious liver diseases. Building on this knowledge, we now want to develop new, preventive and therapeutic strategies to combat these diseases." The initial studies are already under way in the preclinical model.

*Metabolic syndrome: a combination of obesity / abdominal adiposity, insulin resistance, raise levels of lipids in the blood and raised blood pressure.

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The above story is based on materials provided by Helmholtz Zentrum Mnchen - German Research Center for Environmental Health. Note: Materials may be edited for content and length.

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Immune cells in liver drive fatty liver disease, liver cancer

Hillary Clintonhas been working hard to court Silicon Valley, but like many people, shes troubled by our harried, hyper-connected world.

During a keynote speech on Tuesday that was largely about philanthropy and efforts to encourage children to read, she talked about how the U.S. was becoming more politically divided. Americans have become less racist, sexist, and homophobic than ever, she said, but when it comes to politics, they dont want to talk to people who disagree with them. The technological climate has only made that worse, she said onstage at Dreamforce, an annual conference sponsored by Salesforce.com.

We have technological changes that have imposed an almost impulsive reactive challenge to decision-making, she said.

Clinton said that it was becoming harder to build relationships political and otherwise in an age of limited attention spans. (She declined to answer a question about her own political ambitions.)

Dreamforce is a sprawling summit that shuts down San Franciscos downtown. In addition to Clinton, the conference featured well-known speakers, including spiritual teacher Eckhart Tolle and a benefit concert by singer Bruno Mars.

Clinton in her keynote touted her project Too Small to Fail, launched earlier this year through the Clinton Global Initiative. The effort encourages parents to read, talk, and sing to their infants to close the word gap between wealthy and affluent children. UCSF Benioff Childrens Hospital Oakland, named for Salesforce.com CEO Marc Benioff, is a partner in the effort.

Mr. Benioff donated $25,000 to Clintons SuperPAC, Ready for Hillary.

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Clinton Laments Tech-Induced Limited Attention Spans